222 Third Street
Cambridge, Massachusetts

The American Twine Building is an approximately 122,000 SF historic brick and beam office building situated on a nearly 2-acre site in the Kendall Square submarket of Cambridge, Massachusetts. Its Kendall Square location surrounds the building with world-class academic universities, and biotech and tech companies, offering connectivity to a thriving eco-system. With its close proximity to both the Massachusetts Institute of Technology and Harvard University, the Twine Building provides unparalleled access to a deep pool of elite talent, ideal for attracting high-caliber tenants in life science and technology industries. The building is a 10-minute walk from both the Kendall/MIT MBTA Red Line Station and the Lechmere MBTA Green Line Station, and it is located just 1 mile from I-93. NRC affiliate North River Leerink purchased the American Twine Building in 2025.

PROPERTY INFORMATION:

122,000 SF

2 Acres

Historic Brick and Beam Conversion Office Building

106 Parking Spaces

1 Loading Dock